RIPK1-IN-11
RIPK1-IN-11 is a potent, orally bioavailable small molecule inhibitor of RIPK1, demonstrating high affinity (Kd = 9.2 nM) and functional inhibition (IC50 = 67 nM) . It effectively blocks necroptosis in both human and mouse cellular models and shows anti-inflammatory activity, supporting its use in research on inflammatory and neurodegenerative diseases.
Product Specifications
CAS Number
2173557-02-1
Field of Research
Cell Biology, Signal Transduction
Smiles
N (C (=O) C1CC1) C=2SC=3C (N2) =CC=C (C3) C=4C=C (NC (OC5CCOCC5) =O) C (C) =NC4
Molecular Formula
C23H24N4O4S
Molecular Weight
452.53
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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