KRAS inhibitor-18
KRAS inhibitor-18 is a potent small molecule targeting KRAS G12C with an IC50 of 4.74 μM. It effectively inhibits p-ERK in cellular assays, such as in MIA PaCA-2 and A549 cell lines, supporting its research application in pancreatic, colorectal, and non-small cell lung cancer studies.
Product Specifications
CAS Number
2230873-66-0
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
FC=1C=2C (=C (SN2) N3CCN (C (C=C) =O) CC3) C=C (Cl) C1C4=C (F) C=C (F) C (O) =C4
Molecular Formula
C20H15ClF3N3O2S
Molecular Weight
453.87
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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