HDAC1-IN-3

HDAC1-IN-3 is a potent and selective PfHDAC1 inhibitor with broad-spectrum antimalarial activity, effective against both drug-sensitive and multidrug-resistant Plasmodium strains. It demonstrates potent in vitro inhibition and significant in vivo efficacy across all parasitic life cycle stages, making it a valuable chemical probe for epigenetics and antiparasitic research.