Pexidartinib hydrochloride
Pexidartinib hydrochloride (PLX-3397 HCl) is an orally bioavailable, ATP-competitive inhibitor targeting CSF1R (IC50=20 nM) and c-Kit (IC50=10 nM) . It induces apoptosis and is widely used in preclinical research to investigate tumor-associated macrophages and oncology in both in vitro and in vivo models.
Product Specifications
CAS Number
2040295-03-0
Product Name Alternative
PLX3397 hydrochloride, PLX-3397 hydrochloride
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
99.88% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble) ; DMSO:48 mg/mL (105.66 mM)
Smiles
Cl.FC (F) (F) C1=NC=C (C=C1) CNC2=NC=C (C=C2) CC3=CNC=4N=CC (Cl) =CC43
Molecular Formula
C20H16Cl2F3N5
Molecular Weight
454.28
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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