Artemisitene
Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability[1][2].
Product Specifications
CAS Number
[101020-89-7]
UNSPSC
12352005
Target
Apoptosis; Keap1-Nrf2; Topoisomerase
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/artemisitene.html
Purity
99.93
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C=C1[C@@](CC[C@H]2C)([H])[C@@]([C@@]2([H])CC3)(OO4)[C@@](OC1=O)([H])O[C@@]34C
Molecular Formula
C15H20O5
Molecular Weight
280.32
References & Citations
[1]Weimin Chen, et al. Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury. FASEB J. 2016 Jul;30 (7) :2500-10.|[2]Jian Chen, et al. Artemisitene suppresses tumorigenesis by inducing DNA damage through deregulating c-Myc-topoisomerase pathway. Oncogene. 2018 Sep;37 (37) :5079-5087.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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