Dot1L-IN-7
Dot1L-IN-7 (compound 25) is a potent and selective DOT1L inhibitor with an IC50 of 1.0 μM. It demonstrates selective anti-proliferative activity against MLL-rearranged leukemia cells, such as MLL-AF9, in vitro, while sparing E2A-HLF cells, making it a useful chemical probe for epigenetic and cancer research.
Product Specifications
CAS Number
2580940-76-5
Field of Research
Epigenetics & Chromatin
Smiles
C (CNC (CN1N=C (C (NC2=CC=C (C (C) (C) C) C=C2) =O) N=C1) =O) N3C=4C (C=C3) =C (N) N=CN4
Molecular Formula
C23H27N9O2
Molecular Weight
461.52
Storage Conditions
-20°C
Notes
For research use only.
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