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GEM144

GEM144 is an orally bioavailable small molecule that dually inhibits POLA1 and HDAC11. This activity induces p53 acetylation and p21 expression, leading to G1/S cell cycle arrest and apoptosis, making it a useful research tool for oncology studies in both cellular and animal models.

Product Specifications

CAS Number

2487526-28-1

Field of Research

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Purity

98.10% (May vary between batches)

Smiles

O (C (C (NO) =O) C) C1=C (C23CC4CC (C2) CC (C3) C4) C=C (C=C1) C5=CC=C (/C=C/C (O) =O) C=C5

Molecular Formula

C28H31NO5

Molecular Weight

461.55

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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