ZYF0033
ZYF0033 (HPK1-IN-22) is a potent, orally bioavailable HPK1 inhibitor that blocks SLP76 phosphorylation at serine 76. This action enhances anti-tumor immunity, as evidenced by its ability to suppress tumor growth in preclinical in vivo models, making it a valuable tool for immuno-oncology research.
Product Specifications
CAS Number
2380300-79-6
Product Name Alternative
HPK1-IN-22, ZYF 0033
Field of Research
Signal Transduction
Purity
99.70% (May vary between batches)
Solubility
DMSO:80 mg/mL (172.93 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (7.13 mM)
Smiles
OC (C#CC1=CC=CC (=C1) COC=2C=C (C=NC2N) C=3SC (=NC3) C4CCN (C) CC4) (C) C
Molecular Formula
C26H30N4O2S
Molecular Weight
462.61
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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