TDP1 Inhibitor-2
TDP1 Inhibitor-2 is a potent small molecule targeting tyrosyl-DNA phosphodiesterase 1 (TDP1) with an IC50 of 99 nM, and it also inhibits the SCAN1-associated mutant TDP1 (IC50: 3.5 μM) . This compound is a valuable chemical probe for studying DNA repair mechanisms and TDP1-related neurodegenerative diseases in both cellular and biochemical assays.
Product Specifications
CAS Number
859142-95-3
Field of Research
Epigenetics & Chromatin; Pharmacology & Drug Discovery, Metabolism Research
Smiles
O=C1C (C=2C=3C (=CC (OCC4=C (Cl) C=CC=C4Cl) =CC3) OC (=O) C2) =CC=5C (O1) =CC=CC5
Molecular Formula
C25H14Cl2O5
Molecular Weight
465.28
Storage Conditions
-20°C
Notes
For research use only.
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