GNF2133 hydrochloride

GNF2133 hydrochloride is a potent, selective, and orally bioavailable DYRK1A inhibitor (IC50: 6.2 nM) that enhances primary β-cell proliferation and insulin secretion. It is a valuable research tool for studying glucose homeostasis and pancreatic beta-cell regeneration in models of type 1 diabetes, based on in vitro and in vivo experimental data.