NDB
NDB is a potent and selective antagonist of the human farnesoid X receptor alpha (hFXRα) . It effectively blocks GW4064-induced FXR/RXR heterodimerization and suppresses FXR target gene expression in primary mouse hepatocytes, making it a valuable research tool for studying metabolic diseases such as diabetes in both in vitro and in vivo models.
Product Specifications
CAS Number
1660153-08-1
Product Name Alternative
FXR
Field of Research
Metabolism Research
Purity
98.94% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:3.3 mg/mL (7 mM) ; DMSO:80 mg/mL (169.7 mM)
Smiles
CN (C) c1cc (Cl) c (C (=O) N (Cc2ccccc2) c2ccc (O) c (c2) C (C) (C) C) c (Cl) c1
Molecular Formula
C26H28Cl2N2O2
Molecular Weight
471.42
Storage Conditions
-20°C
Notes
For research use only.
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