CRK12-IN-1
CRK12-IN-1 is a potent and selective CRK12 inhibitor with strong trypanocidal activity, exhibiting EC50 values of 1.3 nM against T. b. brucei and 18 nM against T. congolense in vitro. This rapid-acting compound is a valuable chemical tool for researching kinetoplastid biology and validating CRK12 as a drug target for neglected tropical diseases like African sleeping sickness and animal trypanosomiasis.
Product Specifications
CAS Number
1990479-14-5
Product Name Alternative
Trypanosoma brucei
Field of Research
Infectious Disease & Virology
Purity
99.29% (May vary between batches)
Solubility
DMSO:60 mg/mL (126.97 mM)
Smiles
C (=O) (C=1SC (N[C@@H]2CC[C@@H] (NS (CC (C) C) (=O) =O) CC2) =NC1N) C3=C (F) C=CC=C3F
Molecular Formula
C20H26F2N4O3S2
Molecular Weight
472.57
Storage Conditions
-20°C
Notes
For research use only.
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