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ALK-IN-22

ALK-IN-22 is a potent, low-nanomolar inhibitor of ALK and its common resistant mutants (L1196M, G1202R) . It suppresses ALK signaling by reducing phosphorylation of ALK and downstream proteins, leading to apoptosis. This compound is a valuable research tool for investigating ALK-driven tumors in both cellular and animal model systems.

Product Specifications

CAS Number

2468219-09-0

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction

Smiles

C (N (C) C) (=O) C=1C=2C (=CC (NC=3N=C (NC4=C (C (NC) =O) C=CC=C4) C (Cl) =CN3) =CC2) NC1C

Molecular Formula

C24H24ClN7O2

Molecular Weight

477.95

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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