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LX-039

LX-039 is a potent and selective oral estrogen receptor degrader (SERD) with an EC50 of 2.99 nM, featuring an indole C-3 chloride substitution. It demonstrates favorable pharmacokinetics with low clearance and high oral exposure in mice, supporting its investigation for antitumor efficacy in breast cancer research models.

Product Specifications

CAS Number

2135341-09-0

Field of Research

Metabolism Research

Smiles

C (=C (CC) C1=C (Cl) C=C (F) C=C1) (C2=C (Cl) C=3C (N2) =CC=CC3) C4=CC=C (C=CC (O) =O) C=C4

Molecular Formula

C27H20Cl2FNO2

Molecular Weight

480.36

Storage Conditions

-20°C

Notes

For research use only.

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