EGFR/BRAF-IN-1

EGFR/BRAF-IN-1 is a potent dual inhibitor of EGFR and BRAF, notably targeting the BRAFV600E mutant with an IC50 of 45 nM. This 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivative demonstrates potent anti-proliferative activity (GI50=35 nM) in cancer cells and exhibits antioxidant properties, making it a valuable tool compound for oncology research in vitro.