SR12418
SR12418 is a synthetic REV-ERBα/β dual ligand that potently suppresses IL-17A production and Th17 cell differentiation. This activity makes it a valuable research tool for investigating autoimmune pathologies, including experimental models of encephalomyelitis and inflammatory bowel disease.
Product Specifications
CAS Number
1801185-08-9
Product Name Alternative
SR 12418, SR-12418
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research
Purity
99.96% (May vary between batches)
Solubility
DMSO:80 mg/mL (165.44 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (6.82 mM)
Smiles
C (=O) (N1[C@H] (COC2=CC=C (OC (C) (C) C) C=C2) CC=3C (C1) =CC=C (F) C3) C=4C5=C (C=CC4) C=CC=C5
Molecular Formula
C31H30FNO3
Molecular Weight
483.57
Storage Conditions
-20°C
Notes
For research use only.
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