Asciminib hydrochloride
Asciminib hydrochloride (Scemblix) is a STAMP inhibitor that selectively targets the ABL myristoyl pocket. It is used in research for Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML), modulating oncogenic signaling through allosteric binding, as demonstrated in in vitro and in vivo studies.
Product Specifications
CAS Number
2119669-71-3
Product Name Alternative
ABL001 hydrochloride, ABL-001 hydrochloride
Field of Research
Cardiovascular Research, Signal Transduction
Purity
99.91% (May vary between batches)
Solubility
DMSO:80 mg/mL (164.51 mM) ; H2O:< 1 mg/mL (insoluble)
Smiles
C (NC1=CC=C (OC (Cl) (F) F) C=C1) (=O) C2=CC (=C (N=C2) N3CC[C@@H] (O) C3) C=4C=CNN4.Cl
Molecular Formula
C20H19Cl2F2N5O3
Molecular Weight
486.3
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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