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Asciminib hydrochloride

Asciminib hydrochloride (Scemblix) is a STAMP inhibitor that selectively targets the ABL myristoyl pocket. It is used in research for Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML), modulating oncogenic signaling through allosteric binding, as demonstrated in in vitro and in vivo studies.

Product Specifications

CAS Number

2119669-71-3

Product Name Alternative

ABL001 hydrochloride, ABL-001 hydrochloride

Field of Research

Cardiovascular Research, Signal Transduction

Purity

99.91% (May vary between batches)

Solubility

DMSO:80 mg/mL (164.51 mM) ; H2O:< 1 mg/mL (insoluble)

Smiles

C (NC1=CC=C (OC (Cl) (F) F) C=C1) (=O) C2=CC (=C (N=C2) N3CC[C@@H] (O) C3) C=4C=CNN4.Cl

Molecular Formula

C20H19Cl2F2N5O3

Molecular Weight

486.3

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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