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KRAS inhibitor-14

KRAS inhibitor-14 is a potent and selective KRAS G12C inhibitor with an IC50 of 0.249 μM. It demonstrates functional activity by inhibiting p-ERK in cellular assays, such as in MIA PaCA-2 cells, supporting its research application in pancreatic, colorectal, and non-small cell lung cancer models.

Product Specifications

CAS Number

2230873-78-4

Field of Research

Pharmacology & Drug Discovery, Signal Transduction

Smiles

FC=1C=2C (=C (SN2) N3CCN (C (C=C) =O) CC3) C=C (Cl) C1C4=C (Cl) C (Cl) =CC (O) =C4

Molecular Formula

C20H15Cl3FN3O2S

Molecular Weight

486.77

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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