IRAK4-IN-19

IRAK4-IN-19 is a potent and selective IRAK4 inhibitor (IC50 = 4.3 nM) that suppresses LPS-induced IL-23 production in immune cells like THP-1 cells. It has demonstrated efficacy in reducing arthritis severity in preclinical rodent models, making it a valuable chemical probe for researching autoimmune and inflammatory diseases.