BCR-ABL-IN-5
BCR-ABL-IN-5 is a potent inhibitor of both wild-type and T315I mutant Bcr-Abl kinase, with respective IC50 values of 0.014 μM and 0.45 μM. It demonstrates anti-proliferative activity in leukemic cell studies and serves as a valuable research tool for investigating chronic myeloid leukemia (CML) resistance mechanisms in vitro.
Product Specifications
CAS Number
1795736-60-5
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
NC=1C2=C (C=CC=C2NN1) C3=CC=C (C (=O) N4CCN (C (=O) C5=C (Cl) C=C (Cl) C=C5) CC4) C=C3
Molecular Formula
C25H21Cl2N5O2
Molecular Weight
494.37
Storage Conditions
-20°C
Notes
For research use only.
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