FT709
FT709 is a potent and selective inhibitor of the deubiquitinating enzyme USP9X (IC50=82 nM) . By inhibiting USP9X, it reduces cellular levels of Makorin and ZNF598, thereby disrupting ribosomal quality control mechanisms. This tool compound is useful for studying protein homeostasis and ribosome-associated degradation pathways in cellular models.
Product Specifications
CAS Number
2413991-74-7
Product Name Alternative
FT 709
Field of Research
Cell Biology, Molecular Biology, Protein Biochemistry
Purity
98.13% (May vary between batches)
Solubility
DMSO:80 mg/mL (160.48 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (6.62 mM)
Smiles
S (=O) (=O) (N1CC2=C (C1) CN (C ([C@@H] (O) C3=C4C (OC (C) =N4) =CC=C3) =O) C2) C=5C=C6C (=NC5) OCCO6
Molecular Formula
C23H22N4O7S
Molecular Weight
498.51
Storage Conditions
-20°C
Notes
For research use only.
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