NRX-103094
NRX-103094 is a potent small molecule that enhances the binding of phosphorylated β-catenin to the SCFβ-TrCP E3 ligase, with an EC50 of 62 nM and a Kd of 0.6 nM. This action promotes β-catenin degradation, making it a valuable research tool for studying Wnt/β-catenin signaling in cancer and other diseases in both cellular and animal models.
Product Specifications
CAS Number
2763260-36-0
Product Name Alternative
Bcatenin, beta-catenin, betacatenin, NRX 103094, NRX103094, NRX-103094, Wnt/β-catenin, Wnt/betacatenin, Wnt/b-catenin, Wnt, βcatenin, β-catenin
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.56% (May vary between batches)
Solubility
DMSO:40 mg/mL (79.48 mM)
Smiles
S (C1=C (C (NC2=CC (C (O) =O) =CC=C2) =O) C (=O) NC (C (F) (F) F) =C1) C3=C (Cl) C=CC=C3Cl
Molecular Formula
C20H11Cl2F3N2O4S
Molecular Weight
503.28
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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