Penitrem A
Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals[1][2].
Product Specifications
CAS Number
12627-35-9
UNSPSC
12352005
Hazard Statement
H300
Target
Potassium Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/penitrem-a.html
Purity
99.0
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O[C@]12[C@]34[C@@H]([C@H]([C@@H](C(C)=C)O[C@@]4([H])CC[C@@]1([C@]5(C(N6)=C7[C@](OC(C)([C@]8([H])[C@@]([C@]9([H])C8)(O)C%10=C7C6=CC(Cl)=C%10CC9=C)C)([H])[C@]5([H])CC2)C)C)O)O3
Molecular Formula
C37H44ClNO6
Molecular Weight
634.20
Precautions
H300
References & Citations
[1]Goda AA, et al. The Maxi-K (BK) Channel Antagonist Penitrem A as a Novel Breast Cancer-Targeted Therapeutic. Mar Drugs. 2018 May 11;16 (5) .|[2]Norris PJ, et al. Actions of tremorgenic fungal toxins on neurotransmitter release. J Neurochem. 1980 Jan;34 (1) :33-42.|[3]Jortner BS, et al. Effects of prolonged tremor due to penitrem A in mice. Drug Chem Toxicol. 1986;9 (2) :101-16. |[4]Breton P, et al. Brain neurotoxicity of Penitrem A: electrophysiological, behavioral and histopathological study. Toxicon. 1998 Apr;36 (4) :645-55. |[5]Moldes-Anaya A, et al. Neurotoxicity of Penicillium crustosum secondary metabolites: tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice. Toxicon. 2012 Dec 15;60 (8) :1428-35.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
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