What is the catalog number for Penitrem A?

The catalog number for Penitrem A is HY-N6776.

What sizes are available for Penitrem A?

Penitrem A is available in the following size(s): 5 mg.

Is Penitrem A in stock?

Penitrem A is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Penitrem A?

Penitrem A is manufactured by QuantiMol.

What is the estimated delivery time for Penitrem A?

Estimated delivery time for Penitrem A is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Penitrem A?

The safety data sheet for Penitrem A is available here: http://file.medchemexpress.com/batch_PDF/HY-N6776/Penitrem-A-SDS-MedChemExpress.pdf.

Penitrem A

Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals[1][2].

Product Specifications

CAS Number

12627-35-9

UNSPSC

12352005

Hazard Statement

H300

Target

Potassium Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/penitrem-a.html

Purity

99.0

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O[C@]12[C@]34[C@@H]([C@H]([C@@H](C(C)=C)O[C@@]4([H])CC[C@@]1([C@]5(C(N6)=C7[C@](OC(C)([C@]8([H])[C@@]([C@]9([H])C8)(O)C%10=C7C6=CC(Cl)=C%10CC9=C)C)([H])[C@]5([H])CC2)C)C)O)O3

Molecular Formula

C37H44ClNO6

Molecular Weight

634.20

Precautions

H300

References & Citations

[1]Goda AA, et al. The Maxi-K (BK) Channel Antagonist Penitrem A as a Novel Breast Cancer-Targeted Therapeutic. Mar Drugs. 2018 May 11;16 (5) .|[2]Norris PJ, et al. Actions of tremorgenic fungal toxins on neurotransmitter release. J Neurochem. 1980 Jan;34 (1) :33-42.|[3]Jortner BS, et al. Effects of prolonged tremor due to penitrem A in mice. Drug Chem Toxicol. 1986;9 (2) :101-16. |[4]Breton P, et al. Brain neurotoxicity of Penitrem A: electrophysiological, behavioral and histopathological study. Toxicon. 1998 Apr;36 (4) :645-55. |[5]Moldes-Anaya A, et al. Neurotoxicity of Penicillium crustosum secondary metabolites: tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice. Toxicon. 2012 Dec 15;60 (8) :1428-35.