ERCC1-XPF-IN-1
ERCC1-XPF-IN-1 is a high-affinity, potent inhibitor of the ERCC1-XPF endonuclease complex with an IC50 of 0.49 μM. It disrupts nucleotide excision repair, sensitizing cells to DNA-damaging agents like UV radiation and cyclophosphamide in colorectal cancer models, both in vitro and in vivo.
Product Specifications
CAS Number
2411584-25-1
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Smiles
N (C=1C2=C (N=C3C1C=C (O) C=C3) C=C (Cl) C=C2) C4=CC (CN5CCN (CCN (C) C) CC5) =C (O) C=C4
Molecular Formula
C28H32ClN5O2
Molecular Weight
506.04
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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