RET-IN-14
RET-IN-14 is a potent small molecule inhibitor targeting RET wild-type and gatekeeper mutants (V804M, G810R), as well as BTK (C481S), with IC50 values in the low nanomolar range. It is a valuable research tool for investigating RET-driven and BTK-related oncogenesis in both cellular and animal models of cancer.
Product Specifications
CAS Number
2755843-62-8
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
NC=1N2C3=C (C=N2) C (=O) NC[C@H] (C) OC=4C (CN=C (N3) C1C5=CC=C (NC (OC) =O) C=C5) =CC (F) =CN4
Molecular Formula
C24H23FN8O4
Molecular Weight
506.49
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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