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RET-IN-14

RET-IN-14 is a potent small molecule inhibitor targeting RET wild-type and gatekeeper mutants (V804M, G810R), as well as BTK (C481S), with IC50 values in the low nanomolar range. It is a valuable research tool for investigating RET-driven and BTK-related oncogenesis in both cellular and animal models of cancer.

Product Specifications

CAS Number

2755843-62-8

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction

Smiles

NC=1N2C3=C (C=N2) C (=O) NC[C@H] (C) OC=4C (CN=C (N3) C1C5=CC=C (NC (OC) =O) C=C5) =CC (F) =CN4

Molecular Formula

C24H23FN8O4

Molecular Weight

506.49

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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