NRX-252114
NRX-252114 is a potent small molecule that enhances the interaction between mutant β-catenin (pSer33/S37A) and the E3 ubiquitin ligase SCFβ-TrCP, promoting targeted degradation with high affinity (Kd = 0.4 nM) . This molecular glue has been utilized in vitro and in vivo to study Wnt/β-catenin signaling dysregulation in cancer models, offering a research tool for targeted protein degradation.
Product Specifications
CAS Number
2763260-39-3
Product Name Alternative
Beta-catenin, betacatenin, bcatenin, NRX252114, NRX-252114, NRX 252114, Wnt/betacatenin, Wnt/β-catenin, Wnt/b-catenin, Wnt, β-catenin, βcatenin
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.13% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.92 mM) ; DMSO:50 mg/mL (97.98 mM)
Smiles
S (C1=C (C (=O) N2CC=3C (C2) =CC=CC3C#N) C (=O) NC (C (F) (F) F) =C1) C4=C (Cl) C=CC=C4Cl
Molecular Formula
C22H12Cl2F3N3O2S
Molecular Weight
510.32
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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