ATR-IN-18

ATR-IN-18 is a potent and orally bioavailable ATR kinase inhibitor with an IC50 of 0.69 nM. It demonstrates anti-proliferative activity in LoVo colorectal cancer cells (IC50: 37.34 nM) and has shown promising anti-tumor efficacy in research models, supporting its investigation in oncology and DNA damage response studies.