Exatecan-amide-cyclopropanol
Exatecan-amide-cyclopropanol is a potent DNA topoisomerase I inhibitor with sub-nanomolar IC50 values against SK-BR-3 (0.12 nM) and U87 (0.23 nM) cell lines. It is a key research tool for investigating topoisomerase-mediated cytotoxicity in both in vitro and in vivo oncology studies.
Product Specifications
CAS Number
2414254-34-3
Product Name Alternative
ADC Cytotoxin, ADCCytotoxin
Field of Research
Molecular Biology, Pharmacology & Drug Discovery
Purity
98.30% (May vary between batches)
Solubility
DMSO:2 mg/mL (3.85 mM)
Smiles
CC[C@@]1 (O) C (=O) OCc2c1cc1-c3nc4cc (F) c (C) c5CC[C@H] (NC (=O) C6 (O) CC6) c (c3Cn1c2=O) c45
Molecular Formula
C28H26FN3O6
Molecular Weight
519.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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