EGFR kinase inhibitor 1

This potent small molecule EGFR inhibitor exhibits high activity against wild-type (IC50: 37 nM) and L858R/T790M mutant (IC50: 1.7 nM) forms, but not the C797S triple mutant. It demonstrates anti-proliferative effects in vitro by inducing G0/G1 cell cycle arrest and apoptosis, and it has shown anti-tumor and anti-metastatic potential in relevant research models.