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HR-19011

HR-19011 (Compound 40) is a small molecule inducer of eIF2α phosphorylation, leading to increased expression of downstream proteins ATF4 and CHOP. It exhibits anti-proliferative activity in the low micromolar range against K562 leukemia cells and PBMCs in vitro, making it a useful research tool for studying the integrated stress response and cellular apoptosis pathways.

Product Specifications

CAS Number

2851820-52-3

Product Name Alternative

HR19011, EIF2α activator 1

Field of Research

Cell Biology

Purity

99.89% (May vary between batches)

Solubility

DMSO:20 mg/mL (38.21 mM)

Smiles

N (C1=C (N[C@H]2CC[C@H] (OC3=CC=C (C (F) (F) F) C=C3) CC2) C (=O) C1=O) C4=CC (C (F) (F) F) =CC (C#N) =C4

Molecular Formula

C25H19F6N3O3

Molecular Weight

523.43

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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