Cabamiquine (succinate)
Cabamiquine (DDD107498) succinate is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. Cabamiquine succinate inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2[1].
Product Specifications
CAS Number
2444781-71-7
Product Name Alternative
DDD107498 (succinate) ; DDD-498 (succinate) ; M5717 (succinate)
UNSPSC
12352005
Target
CaMK; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cabamiquine-succinate.html
Purity
99.80
Solubility
DMSO : 135 mg/mL (ultrasonic)
Smiles
OC(CCC(O)=O)=O.O=C(C1=CC(C2=CC=C(C=C2)CN3CCOCC3)=NC4=CC=C(C=C41)F)NCCN5CCCC5
Molecular Formula
C31H37FN4O6
Molecular Weight
580.65
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Plasmodium
Available Sizes
Frequently Asked Questions
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