Cabamiquine (succinate)

Cabamiquine (DDD107498) succinate is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. Cabamiquine succinate inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2[1].

Product Specifications

CAS Number

[2444781-71-7]

Product Name Alternative

DDD107498 (succinate) ; DDD-498 (succinate) ; M5717 (succinate)

UNSPSC

12352005

Target

CaMK; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cabamiquine-succinate.html

Purity

99.80

Solubility

DMSO : 135 mg/mL (ultrasonic)

Smiles

OC(CCC(O)=O)=O.O=C(C1=CC(C2=CC=C(C=C2)CN3CCOCC3)=NC4=CC=C(C=C41)F)NCCN5CCCC5

Molecular Formula

C31H37FN4O6

Molecular Weight

580.65

References & Citations

[1]Baragaña B, et al. A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. 2015 Jun 18;522 (7556) :315-20.|[2]Baragaña B, et al. Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy. J Med Chem. 2016 Nov 10;59 (21) :9672-9685.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

Plasmodium

Available Sizes

Curated Selection

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