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EGFR-IN-60

EGFR-IN-60 is an orally bioavailable small molecule inhibitor targeting EGFR (including WT, T790M, and L858R mutants) and JAK3, demonstrating potent in vitro activity in relevant cell lines. It promotes apoptosis by modulating the Bax/Bcl-2 ratio, supporting its investigation as a potential antitumor agent in cancer research.

Product Specifications

CAS Number

2699877-43-3

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction

Smiles

O=C1C=2C (C3=C (NC2CC (C) (C) C1) N=CN (N=CC4=CC=C (N (C) C) C=C4) C3=N) C5=C (Cl) C (Cl) =CC=C5

Molecular Formula

C28H28Cl2N6O

Molecular Weight

535.47

Storage Conditions

-20°C

Notes

For research use only.

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