EGFR-IN-60
EGFR-IN-60 is an orally bioavailable small molecule inhibitor targeting EGFR (including WT, T790M, and L858R mutants) and JAK3, demonstrating potent in vitro activity in relevant cell lines. It promotes apoptosis by modulating the Bax/Bcl-2 ratio, supporting its investigation as a potential antitumor agent in cancer research.
Product Specifications
CAS Number
2699877-43-3
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
O=C1C=2C (C3=C (NC2CC (C) (C) C1) N=CN (N=CC4=CC=C (N (C) C) C=C4) C3=N) C5=C (Cl) C (Cl) =CC=C5
Molecular Formula
C28H28Cl2N6O
Molecular Weight
535.47
Storage Conditions
-20°C
Notes
For research use only.
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