Cbl-b-IN-3
Cbl-b-IN-3 is a highly potent and selective small molecule inhibitor of the E3 ubiquitin ligase Cbl-b, exhibiting an IC50 of less than 1 nM. This compound is a valuable research tool for investigating Cbl-b's role in modulating T-cell activation and immune tolerance in both cellular and animal models of autoimmunity and cancer immunotherapy.
Product Specifications
CAS Number
2573775-59-2
Product Name Alternative
E2Enzyme, E3 Enzyme, E3Enzyme, Cbl, E1 Enzyme, E1/E2/E3 Enzyme, E1Enzyme, E2 Enzyme
Field of Research
Cancer Biology, Protein Biochemistry
Purity
97.63% (May vary between batches)
Solubility
DMSO:11.15 mg/mL (20.74 mM)
Smiles
CN1C ([C@]2 (C[C@@H] (C) C2) C3=CC (=CC=C3) N4CC=5C (C4=O) =CC (CN6C[C@@H] (C) CCC6) =CC5C (F) (F) F) =NN=C1
Molecular Formula
C30H34F3N5O
Molecular Weight
537.62
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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