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Cbl-b-IN-3

Cbl-b-IN-3 is a highly potent and selective small molecule inhibitor of the E3 ubiquitin ligase Cbl-b, exhibiting an IC50 of less than 1 nM. This compound is a valuable research tool for investigating Cbl-b's role in modulating T-cell activation and immune tolerance in both cellular and animal models of autoimmunity and cancer immunotherapy.

Product Specifications

CAS Number

2573775-59-2

Product Name Alternative

E2Enzyme, E3 Enzyme, E3Enzyme, Cbl, E1 Enzyme, E1/E2/E3 Enzyme, E1Enzyme, E2 Enzyme

Field of Research

Cancer Biology, Protein Biochemistry

Purity

97.63% (May vary between batches)

Solubility

DMSO:11.15 mg/mL (20.74 mM)

Smiles

CN1C ([C@]2 (C[C@@H] (C) C2) C3=CC (=CC=C3) N4CC=5C (C4=O) =CC (CN6C[C@@H] (C) CCC6) =CC5C (F) (F) F) =NN=C1

Molecular Formula

C30H34F3N5O

Molecular Weight

537.62

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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