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Thi-DPPY

Thi-DPPY is a potent and orally active dual inhibitor of JAK3 (IC50: 1.38 nM) and BTK (IC50: 62.4 nM) . It demonstrates anti-proliferative effects in HBE cells in vitro and exhibits anti-inflammatory activity in vivo, showing research potential for idiopathic pulmonary fibrosis (IPF) and related inflammatory disease models.

Product Specifications

CAS Number

2307699-34-7

Field of Research

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Smiles

O (C1=C2C (=NC (NC3=CC (Cl) =C (OCCCN4CCOCC4) C=C3) =N1) C=CS2) C5=CC (NC (C=C) =O) =CC=C5

Molecular Formula

C28H28ClN5O4S

Molecular Weight

566.07

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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