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LI-2242

LI-2242 is an inositol hexakisphosphate kinase (IP6K) inhibitor. LI-2242 has inhibition effect for IP6K1, IP6K2, IP6K3 and IPMK with IC50 values of 31 nM, 42 nM, 8.7 nM and 1944 nM, respectively. LI-2242 can be used for thew research of type II diabetes, obesity, metabolic complications, venous thrombosis, and psychiatric disorders[1].

Product Specifications

CAS Number

[2762762-17-2]

UNSPSC

12352005

Target

IPK Superfamily

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/li-2242.html

Purity

98.95

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C2NC(C3(CCN(CC3)CC4=CC=C(C=C4Cl)Cl)C2=C1)=O)O

Molecular Formula

C20H18Cl2N2O3

Molecular Weight

405.27

References & Citations

[1]Liao G, et al. Identification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening. ACS Pharmacol Transl Sci. 2021;4 (2) :780-789. Published 2021 Mar 3.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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