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KIRA9

KIRA9 is a potent IRE1 inhibitor with an IC50 of 4.8 μM in INS-1 cells, acting by competitively occupying the ATP-binding site. This mechanism blocks ER-associated mRNA decay and apoptosis, making it a valuable tool for studying ER stress in models of diabetes and neurodegenerative disease.

Product Specifications

Field of Research

Cell Biology

Molecular Formula

C27H27F3N6O3S

Molecular Weight

572.6

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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