KIRA9
KIRA9 is a potent IRE1 inhibitor with an IC50 of 4.8 μM in INS-1 cells, acting by competitively occupying the ATP-binding site. This mechanism blocks ER-associated mRNA decay and apoptosis, making it a valuable tool for studying ER stress in models of diabetes and neurodegenerative disease.
Product Specifications
Field of Research
Cell Biology
Molecular Formula
C27H27F3N6O3S
Molecular Weight
572.6
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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