G12Si-5
G12Si-5 is a covalent inhibitor targeting the K-RasG12S mutant, binding its S-IIP domain with a Ki of 26 μM to suppress oncogenic signaling. It effectively reduces ERK phosphorylation in KRAS G12S mutant cell lines, making it a valuable tool for in vitro cancer research, though its powder form is unstable, necessitating stabilized salt formulations.
Product Specifications
CAS Number
2946593-46-8
Field of Research
Signal Transduction
Smiles
C (OC=1N=C (C2=C (N1) C (F) =C (N=C2) C=3C4=C (C=CC3) C=CC=C4Cl) N5C[C@]6 ([C@@] (CC5) (C (=O) O6) [H]) [H]) C78N (CCC7) CCC8
Molecular Formula
C31H29ClFN5O3
Molecular Weight
574.05
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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