RORγt/DHODH-IN-3

RORγt/DHODH-IN-3 ((S) -14d) is a potent, orally bioavailable dual inhibitor targeting RORγt and DHODH with IC50 values of 0.098 μM and 0.432 μM, respectively. It demonstrates significant anti-inflammatory activity in vivo, making it a valuable chemical probe for researching autoimmune diseases like psoriasis and multiple sclerosis in both cellular and animal models.