EGFR/HER2-IN-4

EGFR/HER2-IN-4 is an orally bioavailable, irreversible dual inhibitor of EGFR, effective against mutant forms including L858R/T790M (IC50: 0.6 nM) . It demonstrates potent kinase inhibition in vitro and significant anti-tumor efficacy in vivo, making it a valuable chemical probe for non-small cell lung cancer research.