AKI603
AKI603 is a potent and selective Aurora kinase A (AurA) inhibitor with an IC50 of 12.3 nM. It was developed to target BCR-ABL-T315I mutation-driven resistance, demonstrating robust anti-proliferative effects in leukemic cell lines in vitro and showing potential for leukemia research.
Product Specifications
CAS Number
1432515-73-5
Product Name Alternative
Imatinib-resistant, leukemia, Inhibitor, inhibit, myeloid, AKI 603, AKI603, AKI-603, Aurora A, AuroraKinase, Aurora Kinase, CML, chronic
Field of Research
Cell Biology, Epigenetics & Chromatin
Purity
99.78% (May vary between batches)
Solubility
DMSO:120 mg/mL (293.08 mM)
Smiles
CN1CCN (CC1) c1cc (Nc2cc (C) [nH]n2) nc (Nc2ccc (cc2) [N+] ([O-]) =O) n1
Molecular Formula
C19H23N9O2
Molecular Weight
409.45
Storage Conditions
-20°C
Notes
For research use only.
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