AZD0780
AZD0780 is an orally bioavailable small molecule PCSK9 inhibitor that binds the C-terminal domain of PCSK9. It disrupts lysosomal trafficking of the PCSK9-LDLR complex to prevent LDL receptor degradation, making it a valuable research tool for investigating hypercholesterolemia in both cellular and animal models.
Product Specifications
CAS Number
2455427-91-3
Product Name Alternative
AZD 0780, AZD0780, AZD-0780, PCSK9, PCSK9-IN-12, EX-A 6975, EX-A6975, EX-A-6975
Purity
97.61% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (7.96 mM) ; DMSO:247.5 mg/mL (597.23 mM)
Smiles
FC (F) Oc1cnc (N[C@H]2CC[C@@H] (C2) Nc2ccc (cn2) -n2ccccc2=O) nc1
Molecular Formula
C20H20F2N6O2
Molecular Weight
414.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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