LH2-051

LH2-051, a lysosome-enhancing compound (LYEC), is a brain-penetrant dopamine transporter (DAT) inhibitor (Ki: 0.95 μM) . LH2-051 inhibits DAT-mediated dopamine uptake with an IC50 of 3.0 μM. LH2-051 promotes nuclear translocation of TFEB and lysosome biogenesis. LH2-051 improves the memory of amyloid precursor protein (APP) /Presenilin 1 (PS1) mice. LH2-051 can be used for the study of Alzheimer’s disease[1].

Product Specifications

CAS Number

[2358754-22-8]

UNSPSC

12352005

Target

CDK; Dopamine Transporter

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lh2-051.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(OC)C=C(C(CCC2=CNC3=C2C=CC=C3)N(CC4CCOCC4)CC5)C5=C1

Molecular Formula

C27H34N2O3

Molecular Weight

434.57

References & Citations

[1]Yin L, et al. Inhibition of the dopamine transporter promotes lysosome biogenesis and ameliorates Alzheimer's disease-like symptoms in mice. Alzheimers Dement. 2023 Apr;19 (4) :1343-1357.