LH2-051
LH2-051, a lysosome-enhancing compound (LYEC), is a brain-penetrant dopamine transporter (DAT) inhibitor (Ki: 0.95 μM) . LH2-051 inhibits DAT-mediated dopamine uptake with an IC50 of 3.0 μM. LH2-051 promotes nuclear translocation of TFEB and lysosome biogenesis. LH2-051 improves the memory of amyloid precursor protein (APP) /Presenilin 1 (PS1) mice. LH2-051 can be used for the study of Alzheimer’s disease[1].
Product Specifications
CAS Number
[2358754-22-8]
UNSPSC
12352005
Target
CDK; Dopamine Transporter
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lh2-051.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C(OC)C=C(C(CCC2=CNC3=C2C=CC=C3)N(CC4CCOCC4)CC5)C5=C1
Molecular Formula
C27H34N2O3
Molecular Weight
434.57
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Rat NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2) ELISA Kit
Rat NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2) ELISA Kit
Rat NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2) ELISA Kit
ARHGEF11 (Rho Guanine Nucleotide Exchange Factor 11, PDZ-RhoGEF, KIAA0380, DKFZp667F1223, GTRAP48) (MaxLight 550)
