Varlitinib
Varlitinib (ASLAN001) is a reversible pan-EGFR inhibitor with potent activity against HER1 (IC50=7 nM), HER2 (IC50=2 nM), and HER4 (IC50=4 nM) . It is a research tool used in vitro and in vivo for studying EGFR-driven cancers, including biliary tract and gastric malignancies.
Product Specifications
CAS Number
845272-21-1
Product Name Alternative
ARRY 334543, ARRY334543, ARRY-334543, ASLAN001, ASLAN-001, ASLAN 001, HER1, HER2, HER4, Varlitinib
Field of Research
Cardiovascular Research, Signal Transduction
Purity
99.51% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.28 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:31.5 mg/mL (67.46 mM)
Smiles
C[C@@H]1COC (Nc2ccc3ncnc (Nc4ccc (OCc5nccs5) c (Cl) c4) c3c2) =N1
Molecular Formula
C22H19ClN6O2S
Molecular Weight
466.94
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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